worry stress

worry stress

People who are depressed often find themselves preoccupied with guilty, shameful, or self-defeating thoughts. These thoughts not only distract them from other activities, but also do nothing to resolve the underlying issues. And, the ideas that receive focused attention in these depressive ruminations are frequently quite distorted and lead to distress.

The way that people with depression repetitively attend to negative thoughts is unproductive. Scientists use the term ruminations to describe these thoughts, because they call to mind the repetitive chewing of cud by ruminants like cows and goats.

The tendency for rumination in depression has been well characterized, but a new study by Dr. J. Paul Hamilton at the Laureate Institute for Brain Research at Stanford University sheds light on the brain mechanisms that are involved.

The researchers’ work highlights the interplay of a brain region implicated in depression, the subgenual prefrontal cortex (sgPFC) and a brain network involved in reflection, sometimes called the default mode network (DMN). The DMN becomes activated when the brain’s task-oriented circuits are not engaged, i.e., during times of self-referential thought.

By reanalyzing existing studies, Hamilton and colleagues show that depressive ruminations are more likely to emerge in depression when the firing of the sgPFC, signaling depressed mood, is more tightly coordinated with the firing of the DMN. They propose that the observed increased connectivity reflects a functional integration of sgPFC and DMN processes which, in turn, support rumination in depression.

“This study shows that depression distorts a natural process. It would seem that normally the subgenual prefrontal cortex helps to bias the reflective process supported by the default mode network so that we can consider important problems in the service of developing strategies for solving them,” commented Dr. John Krystal, Editor of Biological Psychiatry.

“However, in depression it seems that the subgenual prefrontal cortex runs amok hijacking normal self-reflection in a maladaptive way. This may be one reason that electrical stimulation of the sgPFC is helpful for some patients with severe or treatment-resistant symptoms of depression.”

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