What is Hyperforin?

Hyperforin is a principal component of St. John’s wort, along with other extracts such as Hypericin and Ad-Hyperforin. It is the main active constituent responsible for SJW’s antidepressant effects.

Where is it found?

Hyperforin is found in the St. John’s wort plant, also called hypericum. Hyperforin is naturally occuring in St. John’s Wort at 2% to 4% concentration, depending on the specific plant, region and season. While standardized extracts of hyperforin are available, it is noteworthy to mention that stanardized extracts of 3% or more have been found to be unstable and will usually return to the naturally occurring levels within several weeks.

What is it used for?

Hyperforin has been shown to inhibit the uptake of dopamine, noradrenaline, GABA, 5-HT (Serotonin) and glutamate. St. John’s wort is used as an effective option in treating mild to moderate depressive disorders. The antibiotic compound the plant produces is hyperforin. How effective SJW is in treating depression depends on its hyperforin content.

Hyperforin, by way of St. John’s wort, has also shown some benefit when used as an anti-inflammatory, astringent and antiseptic, but is most often used as an antidepressant.

How is it taken?

Hyperforin is found in St. John’s wort, which is often taken in the form of an herbal supplement. It may be prepared as an infusion from the dried herb, a liquid extract, or in capsule or pill form as a dietary supplement.

It remains in the bloodstream for several hours after St. John’s wort is ingested.